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Center for Clinical Genomics
The Center for Clinical Genomics (CCG) applies human genetics to clinical research. The CCG provides study design expertise and the infrastructure to collect, organize, and maintain a collection of clinical information and biologic materials from individuals with various conditions who have been identified during routine clinical care at the UW Medical Center, Seattle Children’s, the Fred Hutchinson Cancer Research Center and Group Health.
Services
The CCG can help you with:
- Experimental design of the genetic component of clinical studies
- Development and writing human-subject protocols
- Design of data capture forms and questionnaires
- Collection and tracking of phenotypic information
- Logistical coordination among regulatory boards, clinical centers, and research programs
- Identification of suitable technologies for processing and analyzing genetic material
- Identification of resources and colleagues from the UW Medical Center, Seattle Children’s, and the Fred Hutchinson Cancer Research Center who can make available such technologies
- DNA extraction from a variety of tissues
- Tissue banking and long-term storage
- Support for management of clinical, sample storage, and genetic analysis data
How researchers use this resource or service
Genetic modifiers of cystic fibrosis (CF). Researchers at Seattle Children’s are studying a group of 1,700 CF patients living throughout the United States to better understand health problems associated with CF disease. A major health problem in children with CF is a bacterial lung infection called Pseudomonas aeruginosa (Pa). Investigators are examining factors, such as nutritional status and genetics, that may that influence time to Pa acquisition as well as the severity of the infection. This study may lead to the ability to predict the onset of infection and the development of preventive measures. The CCG is processing blood obtained from CF patients and banking DNA for future studies. The CCG is also providing guidance for the design of studies looking at genetic factors that may affect many other CF outcomes.
StarNet. StarNet is a science education curriculum developed by the UW Departments of Genome Sciences and Medicine, Division of Medical Genetics. The StarNet curriculum involves high school students in designing and implementing a research investigation, a case-control study aimed at detecting the association of genetic and environmental factors with smoking behavior. For this study anonymous adults complete a questionnaire and give a blood sample for DNA. Under the direction of their classroom teachers, students are carrying out several aspects of this investigation, including formulating hypotheses, helping design the questionnaire, genotyping samples, and analyzing data. The CCG is responsible for recruiting, enrolling, administering the questionnaire and collecting and processing blood samples from 250 smokers and 250 non-smokers living in the Puget Sound area.
Fees
The CCG provides a variety of free and fee-based services to ITHS members. We are currently considering fees on a case-by-case basis.
Last modified: March 2, 2009