Seattle Structural Genomics Center for Infectious Disease (SSGCID)

SSGCID provides structural genomics services to the research community and publicly disseminates all structure information and material resources generated as part of the NIAID contract. Organisms from which targets may be nominated are from the NIAID category A-C, emerging and re-emerging diseases lists. View organism list and nominate targets at http://www.ssgcid.org/home/Community.asp. SSGCID achieves its goal through employment of a high-throughput gene-to-structure pipeline involving a multi-pronged serial escalation approach to protein expression in bacterial, wheat-germ cell-free translation, baculovirus and mammalian systems followed by structure solution using X-ray crystallography and NMR spectroscopy. Proactive engagement of the infectious disease research and drug therapy communities in the target selection process will help ensure that the resulting protein structures provide a blueprint for structure-based drug design of new therapeutics to combat infectious diseases. This goal will further be facilitated by the annual selection of a small number of high-impact targets for a fragment-based drug lead discovery campaign within SSGCID.

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