Development of Multidimensional Gas Chromatography-Mass Spectrometry Methods for Metabolomics

We are developing and implementing advanced analytical chemistry technology (instrumentation, methodology and software) using gas chromatography (GC), mass spectrometry (MS), solid phase micro extraction (SPME) sampling, and chemometrics (multivariate data analysis) to provide solutions in several application areas: health biomarker discovery, food safety and security, forensics, environmental, and industrial discovery. In this presentation, the focus will be on metabolomics.  For chemical measurements at the discovery stage, instrumentation must provide a highly informative chemical signature.  For this we combine comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GC x GC - TOFMS), and chemometrics.

Robert E. Synovec, Professor
Associate Chair, Graduate Program
Faculty Director, Center for Process Analytical Chemistry
Department of Chemistry, Box 351700
University of Washington, Seattle, WA 98195, USA
Email: synovec@chem.washington.edu