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2018-2019 Request for Applications

ITHS Translational Pilot Award with a Special Emphasis on Diabetes

ITHS Translational Pilot Award with a Special Emphasis on Diabetes

2018-2019 RFA

ITHS is offering a Translational Pilot Award with a Special Emphasis on Diabetes in conjunction with the Diabetes Research Center to support studies that address impactful research issues within the translational science spectrum, with the long-term goal of improving the health of patients with diabetes.

Examples might include pre-clinical work with animal models, clinical observational or implementation studies, or public health outcomes research related to diabetes and its complications.

Application Period Open
Key Dates

The following key dates apply to this funding opportunity:

  • Application Deadline
    September 1, 2017
  • Awardees Notified
    December 1, 2017
  • Period of Performance
    March 1, 2018 – February 28, 2019

This pilot award will provide up to $25,000 in total direct costs for one year. No-cost extensions will not be permitted.

Priority for support will be given to junior investigators at or below the rank of Assistant Professor or equivalent. Established investigators will be considered only if work proposed encompasses a translational project that differs significantly from their current research directions.

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Fostering and supporting both basic and clinical research in diabetes and related metabolic disorders...

More Information

Learn more about the Diabetes Research Center.

Guidelines
Guidelines
  1. Successful applications will address a critical knowledge gap in type 1 or type 2 diabetes and represents a key step toward improvement in the treatment or prevention of disease. The project must demonstrate significant scientific merit and provide a vision of how it could evolve to a more substantial body of work.Examples of projects that would be considered responsive to this RFA include (but are not limited to):
    • Investigations into basic cellular processes involved in glucose metabolism or the regulation of insulin signaling with the use of in vitro cell culture models or primary cells.
    • Animal studies with dietary, pharmacologic or genetic interventions to improve our understanding of glucose tolerance, insulin sensitivity, pancreatic b-cell function or diabetic complications.
    • Human observational or epidemiological studies to identify risk factors for type 1 or type 2 diabetes or complications of diabetes.
    • Randomized controlled trials of diet or other lifestyle interventions, investigational drugs or devices, or other interventions (e.g. bariatric surgery) to assess their impact on glycemic control, glucose tolerance or complications of diabetes.
  2. Plan to spend your money in 1 year. No-cost extensions will not be allowed. ITHS faculty or staff may be listed as active research contributors on a case-by-case basis. Please consult with ITHS prior to application submission if your proposal includes ITHS faculty or staff.
Eligible Investigators
Eligible Investigators

Faculty members at ITHS Partner Institutions, including the University of Washington, Fred Hutch Cancer Research Center, Seattle Children’s Research Institute, and other academic institutions affiliated with the ITHS in the WWAMI (Washington, Wyoming, Alaska, Montana, Idaho) region are eligible to apply for this pilot award. Collaborations may extend outside the WWAMI region; however, funds may not be transferred outside the United States. ITHS-funded faculty and staff are ineligible to apply. An acting faculty member or instructor is eligible to apply only if the Department head provides a letter supporting the applicant’s eligibility to serve as PI.

All Investigators on the research team must be ITHS Members in order to apply. To become a member, please complete the ITHS Membership Form.

Application Process
Application Process
A. Application

The application must be submitted through the ITHS website.

Applications will follow National Institutes of Health (NIH) formatting guidelines (see FAQ) and include:

95 KB1) Cover Page
2) Project Title and Abstract (250 word maximum)
3) Research Plan, 2-pages (references do not count toward page limit)
57 KB4) Project Timeline – 1-page
5) Budget and Budget Justification 29 KB6a) Budget 37 KB6b) Budget Justification
6) Letter(s) of Support Letters of Support are not required unless you are an instructor or acting faculty member. If you are an instructor or acting faculty member, you will need to include a letter supporting your eligibility to serve as PI from your Department head (or equivalent).
35 KB7) NIH format Biosketches for all investigators (senior/key personnel)
Not included in the above document:

Suggested Reviewers – You will also be asked to provide five suggested reviewers, including the following information for each: 1) Name, 2) Title, 3) Institution/Organization, and  4) Email Address.
A general note about conflict of interest: A reviewer would have a conflict of interest if they are the applicant’s mentor, dept. chair, spouse, or close relative; or if they currently work together on manuscripts, grants, or business ventures. Simply being in the same department or division is not, in and of itself, a conflict of interest.

B. Timeline

  • Application Deadline – September 1, 2017
  • Scientific Review – September 2017 – November 2017
  • Awardees Notified – December 1, 2017
  • Just-in-Time Process – December 2017 – February 2018
  • Period of Performance – March 1, 2018 – February 28, 2019

ITHS is funded through a CTSA grant from NIH’s National Center for Advancing Translational Sciences (NCATS). NCATS requires the review and approval of all pilot grants involving human subjects research before funds are released. Therefore, if your proposal is awarded funding and involves human subjects research, additional documentation will be required. NCATS review and IRB review can be concurrent, but final NCATS approval is contingent upon IRB approval.

Frequently Asked Questions
FAQs

How could I find out whether my idea is a good fit for a Translational Diabetes Research Award?

All investigators considering whether to submit an application for this award are encouraged to contact the ITHS. ITHS can provide referrals to possible collaborators and consultants who could assist with the development of your project.

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Are there any restrictions on indirect costs applied to these awards?

Applicant institutions must use a rate no higher than the approved, federally recognized indirect cost rate negotiated between the applicant institution and the federal government. ITHS would like to maximize funds to directly support the investigator’s research and encourages investigators to work with their Office of Sponsored Programs to obtain a waiver to reduce indirect costs on the project.

The Fred Hutchinson Cancer Research Center and Seattle Children’s have agreed to consider requests for indirect cost waivers for ITHS pilot awards from their faculty. ITHS members whose research program are based at Fred Hutch or Seattle Children’s and who wish to apply for ITHS pilot awards are required to go through the standard institutional procedure for requesting a waiver of facilities and administrative (F&A) costs.

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Do our suggested reviewers need to be a part of the University of Washington?

No. A reviewer may come from any academic institution, community-based organization, or industry leader. A general note about conflict of interest: A reviewer would have a conflict of interest if they are the applicant’s mentor, department chair, spouse, or close relative; or if they currently work together on manuscripts, grants, community-based work, or business ventures. Simply being in the same department or Division is not, in and of itself, a conflict of interest.

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University of Washington specific question: Does this award have to go through the Office of Sponsored Programs (OSP)? Is an eGC1 required?

No, this is an internal grant and does not need to be routed through OSP and does not require an eGC1.

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Do figures and references count toward the 2-page Research Plan limit?

Figures DO count toward the 2-page limit but references can be in addition to the 2-page Research Plan.

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Are there any formatting requirements?

Applications will follow National Institutes of Health (NIH) formatting guidelines (https://grants.nih.gov/grants/how-to-apply-application-guide/format-and-write/format-attachments.htm), including the following:

Font (size, color, type density) and Line Spacing

  • Font size: must be 11 points or larger (smaller text in figures, graphs, diagrams and charts is acceptable as long as it is legible when the page is viewed at 100%).
  • Type density: must be no more than 15 characters per linear inch (including characters and spaces)
  • Line spacing: must be no more than six lines per vertical inch.
  • Text color: must be black (color text in figures, graphs, diagrams, charts, tables, footnotes and headings is acceptable).
  • We recommended the following fonts, although other fonts (both serif and non-serif) are acceptable if they meet the above requirements:
    • Arial
    • Garamond
    • Georgia
    • Helvetica
    • Palatino Linotype
    • Times New Roman
    • Verdana

Citations

  • We do not require a specific citation format.

Paper Size and Margins

  • Use paper size no larger than standard letter paper size (8 ½” x 11”).
  • Provide at least one-half inch margins (top, bottom, left, and right) for all pages. No applicant-supplied information can appear in the margins.

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What is a Contact PI?

ITHS requires the applicant to designate one of the Program Director/Principal Investigator (PD/PI)(s) as the Contact PD/PI. This person is responsible for communication between the PD/PIs and ITHS, but has no special authorities or responsibilities within the project team. In many ways, a contact PD/PI is analogous to a corresponding author on a publication. The Contact PD/PI must serve as a member of the PD/PI team and must meet all eligibility requirements for PD/PI status. In those projects where there is an identified project coordinator, the coordinator could serve as Contact PD/PI or that role could be assigned to another PD/PI. Note that the Contact PD/PI must be associated with the applicant/awarde institution.

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Are supplemental documents allowed?

No, supplemental documents are not allowed.

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Do you expect the PI, Co-PI, or Senior/Key personnel to have a specific amount of effort committed in the form of salary?

ITHS will follow NIH Policy: Each PD/PI must have measurable effort (greater than zero), and the level of effort must be adequate to achieve the proposed goals. The PD/PI and other individuals who contribute to the scientific development or execution of a project in a substantive, measurable way, whether or not they receive salaries or compensation under the grant. Typically these individuals have doctoral or other professional degrees, although individuals at the masters or baccalaureate level may be considered senior/key personnel if their involvement meets this definition. Consultants and those with a postdoctoral role also may be considered senior/key personnel if they meet this definition. Senior/key personnel must devote measurable effort to the project whether or not salaries or compensation are requested. “Zero percent” effort or “as needed” are not acceptable levels of involvement for those designated as Senior/Key Personnel.

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Can there be more than 2 Co-PIs or Multiple PIs?

Yes, you may have more than 2 PIs, however 1 person will be identified as the Contact PI for administrative purposes.

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Can a community or industry partner be my collaborator?

Yes, we as long as the main, or Contact PI must be a faculty member at an academic institution.

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Could an investigator apply for this program with a pending faculty appointment?

Pilot recipients must be a faculty member at an academic institution by June 1, 2017.

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I have previously been awarded funds by the ITHS. Am I still eligible to receive this award?

Yes, previous ITHS awardees are eligible to receive additional funding.

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Can vouchers be dispersed prior to IRB/IACUC approval to aid the application process?

No, vouchers cannot be awarded until IRB/IACUC approval is confirmed.

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Page last modified: Aug 8, 2017 @ 7:44 am (PST)

Cite ITHSThe Institute is supported by grants UL1 TR002319, KL2 TR002317, and TL1 TR002318 from the NIH National Center for Advancing Translational Sciences through the Clinical and Translational Science Awards Program (CTSA).

Please help us continue to support your research by citing our grant number(s) in publications we supported.