19 Jul ADT Study
The purpose of this study is to better understand why androgen deprivation therapy (ADT) increases risk of body weight gain, insulin resistance, and type 2 diabetes in men with prostate cancer.
The specific question we are exploring is whether ADT leads to changes in parts of the brain that regulate appetite and body weight. These changes can be visualized through magnetic resonance imaging (MRI).
At a screening visit, potentially eligible volunteers will be asked about medical history and
medication use. If the volunteer is eligible and chooses to participate, 3 more study visits
will be held over ~7 months. At each of these 3 visits, volunteers will undergo brain and
abdominal MRI. We will measure body fat mass and lean mass with a dual X-ray
absorptiometry (DEXA) scan. Visits will be conducted at baseline [immediately prior to
radiation therapy or surgical therapy and androgen deprivation therapy (ADT)] and 4-5
weeks and 6 months after initiation of ADT (or after surgery/initiation of radiation therapy
for those volunteers who will not undergo ADT).
Volunteers will be compensated for their time, travel, and inconvenience. Discontinuation
from the study will result in prorated compensation.
2. 40-75 years of age
3. Recent diagnosis of new or relapsed, localized prostate cancer to be treated with
radiation therapy or surgical therapy with or without androgen deprivation therapy
4. No chronic disease (heart failure, liver or kidney disease, or diabetes)
5. No implanted metal devices
6. No claustrophobia
Additional Study Details
Full Study Title
The Effect of Androgen Deprivation Therapy on Hypothalamic Gliosis in Men
Katya Rubinow, MD, Associate Professor, Department of Medicine (Principal Investigator)
Ellen Schur, MD, MS, Professor, Department of Medicine
Jonathan Wright, MD, MS, FACS, Associate Professor , Department of Urology
Jay Liao, MD, Associate Professor, Department of Radiation Oncology
Kenneth Russell, MD, Professor, Department of Radiation Oncology
Accepts Healthy Volunteers?
University of Washington – South Lake Union
750 Republican St Building F, 3rd floor
Seattle, Washington 98109