07 Jul APA to Manage Chemotherapy Induced Neuropathy
Chemotherapy-induced neuropathy (CIN) is a major side effect resulting from chemotherapy. It persists even after completion of chemotherapy among ~30-40% of cancer patients, which can negatively impact quality of life. No effective treatment for CIN has been established.
We propose to test auricular point acupressure (APA)—an acupuncture-like stimulation on the ear without needles—so that cancer patients can self-manage their CIN.
We plan to study the mechanisms underpinning pain sensitivity and pain processing due to APA on CIN. Along with the clinical CIN outcomes, outcomes will include physiological change in pain sensory thresholds (measured by quantitative sensory testing, [QST]), brain change associated with pain processing (measured by fMRI), and neuro-transmitters (measured by inflammatory cytokines).
Inclusion criteria. Eligible participants will meet the following criteria:
– Cancer patient ≥18 years
– Completed a course of chemotherapy
– Have CIN symptoms due to cancer treatment
Exclusion criteria. Participants reporting the following will not be eligible:
(1) use of an investigational agent for pain control concurrently or within the past 30 days;
(2) use of an implantable drug delivery system, e.g. Medtronic SynchroMed®;
(3) prior celiac plexus block or other neurolytic pain control treatment;
(4) other identified causes of painful paresthesia existing prior to chemotherapy (e.g., radiation or malignant plexopathy, lumbar or cervical radiculopathy,);
(5) allergy to latex (the tapes for the APA include latex).
Additional Study Details
Full Study Title
Auricular Point Acupressure to Manage Chemotherapy Induced Neuropathy
Dr. Chao Hsing Yeh
Dr. Tom Smith
Accepts Healthy Volunteers?
Johns Hopkins School of Nursing
525 N Wolfe St
Baltimore, Maryland 21205