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APA to Manage Chemotherapy Induced Neuropathy

APA to Manage Chemotherapy Induced Neuropathy

Chemotherapy-induced neuropathy (CIN) is a major side effect resulting from chemotherapy. It persists even after completion of chemotherapy among ~30-40% of cancer patients, which can negatively impact quality of life. No effective treatment for CIN has been established.

We propose to test auricular point acupressure (APA)—an acupuncture-like stimulation on the ear without needles—so that cancer patients can self-manage their CIN.

We plan to study the mechanisms underpinning pain sensitivity and pain processing due to APA on CIN. Along with the clinical CIN outcomes, outcomes will include physiological change in pain sensory thresholds (measured by quantitative sensory testing, [QST]), brain change associated with pain processing (measured by fMRI), and neuro-transmitters (measured by inflammatory cytokines).

Participant Eligibility

Inclusion criteria. Eligible participants will meet the following criteria:
– Cancer patient ≥18 years
– Completed a course of chemotherapy
– Have CIN symptoms due to cancer treatment

Exclusion criteria. Participants reporting the following will not be eligible:
(1) use of an investigational agent for pain control concurrently or within the past 30 days;
(2) use of an implantable drug delivery system, e.g. Medtronic SynchroMed®;
(3) prior celiac plexus block or other neurolytic pain control treatment;
(4) other identified causes of painful paresthesia existing prior to chemotherapy (e.g., radiation or malignant plexopathy, lumbar or cervical radiculopathy,);
(5) allergy to latex (the tapes for the APA include latex).


Kate Turkot
(202) 813-9525

Additional Study Details

Full Study Title
Auricular Point Acupressure to Manage Chemotherapy Induced Neuropathy

Study ID: IRB00243141
Start Date: 07/08/2021
End Date: 12/30/2022

Dr. Chao Hsing Yeh
Dr. Tom Smith

Accepts Healthy Volunteers?

Study Site(s)

Johns Hopkins School of Nursing

525 N Wolfe St
Baltimore, Maryland 21205


Use the link below to send a message to the study coordinator, or call the number above to speak directly with a study representative.

I am interested in this research study.