24 Jan Effect of Estrogen Treatment on Drug Metabolism and Transport
Gender-affirming hormone therapy may include estradiol, a hormone that the body creates and uses naturally. Estradiol is prepared as a medication that patients may take to increase hormone levels. Changes in estradiol concentrations in the body may affect how the body processes other medicines. The purpose of this study is to find out how estradiol therapy affects a single tracer dose of approved medicines in the blood (midazolam, digoxin, and acetaminophen) and to confirm estradiol treatment does not affect natural bacterial in the gut.
Inclusion Criteria:1) Self-identified trans* adult at least 18 years of age. 2) Not taking estrogen treatment currently. 3) Transgender adults planning to take oral or injectable estradiol treatment. Exclusion Criteria: 1) Unwilling/unable to return for project follow-up visits. 2) Unwilling/unable to provide written informed consent.
Additional Study Details
Full Study Title
Effect of gender-affirming estrogen therapy on drug metabolism, transport, and gut microbiota
Lauren Cirrincione, PharmD (she/her)
Accepts Healthy Volunteers?
UNIVERSITY OF WASHINGTON
1959 NE Pacific St
Seattle, Washington 98195