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Fish and Fiber

Fish and Fiber

The purpose of this research is to understand the combined effect of fish oil and fiber. There have been many studies looking at them separately, but not together. Studies in animals have shown that the combination reduces colon tumor formation. We are interested in understanding how the combination works in the human body and what potential it may have to prevent colon cancer. We will look at changes in health markers in blood and stool as well as changes in the intestinal microbial communities (as seen in the stool).

Participants go through two study periods. During one study period they incorporate fish oil and a fiber powder (all provided by the study) to their usual diet. During the other period they take the “placebo” (supplements that look exactly like the fish oil ones but contain corn oil instead, and a powder that is a similar corn product but is not considered a fiber). Half the participants start with the fish oil plus fiber supplements, and the other half will start with the placebo supplements. All participants go through both periods.

Details and initial questionnaire at: http://www.FishAndFiber.com

Participant Eligibility

Individuals from the Greater Seattle area who are normal to overweight (BMI of 18-30 kg/m2) and between the ages of 50-75, who typically consume diets with 20g fiber or less per day.

The exclusion criteria will address a mix of medical and practical issues: 1) chronic medical illness, history of gastrointestinal disorders (e.g., ulcerative colitis, Crohn disease, celiac sprue, HNPCC, familial adenomatous polyposis, pancreatic disease, previous gastrointestinal resection, radiation or chemotherapy, and cancer (other than non-melanoma skin cancer); 2) weight change greater than 4.5 kg within past year; 3) oral or IV antibiotic use within the past 3 months; 4) regular use of aspirin or NSAIDs; 5) smoking; 6) known allergy to fish; 7) intention to relocate out of study area within next 4 months; 8) abnormal liver/kidney functions as ascertained at a baseline blood draw.


Lisa Levy
(206) 667-6340

Additional Study Details

Full Study Title
Diet and the Colonic Exfoliome: A Novel, Non-invasive Approach to Testing Interventions in Humans

Study ID: IRB 10327 RG1006100
Start Date: 11/13/2019
End Date: 02/26/2022

Dr. Johanna Lampe
Dr. Meredith Hullar
Dr. Robert Chapkin
Dr. Sandi Navarro

Accepts Healthy Volunteers?

Study Site(s)

Fred Hutch in South Lake Union

1100 Fairview Ave N
Seattle, Washington 98109


Use the link below to send a message to the study coordinator, or call the number above to speak directly with a study representative.

I am interested in this research study.