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Kidney Stone Smart Water Bottle Study

Kidney Stone Smart Water Bottle Study


The Urinary Stone Disease Research Network (USDRN) is conducting a kidney stone prevention trial entitled Prevention of Urinary Stones with Hydration (PUSH) and is funded by the National Institutes of Health (NIH).

PUSH is a 2-year randomized controlled trial assessing a program of behavioral interventions to increase fluid intake and adherence in order to decrease kidney stones. Participants in the intervention arm will receive an individualized “fluid prescription”, incentives for meeting daily fluid goals and coaching to overcome fluid intake barriers. Control arm participants will undergo usual stone prevention care, be informed about the goal urine output recommended by the AUA, and also receive a smart water bottle. The only in-person visits for PUSH are at the beginning and end of study for a low dose CT or ultrasound. All other contacts are remote including 24-hour urine home collections done at several points throughout the follow-up period.

In 2020, we are now enrolling out of the area participants with a study modification that allows for complete remote enrollment without needing to come to the study site for any visits.

Participant Eligibility

Inclusion Criteria:
– At least 12 years old
– A symptomatic stone event (passage or procedural intervention) within 3-5 years prior to enrollment
– 24-hour urine volume less than 2 liters (if known)
– You own and are willing to use a smartphone or other device (e.g. tablet) compatible with the study-provided wireless “smart” water bottle

Exclusion Criteria:
– Spinal cord injury
– Currently undergoing active treatment for cancer except basal cell skin cancer, or patients with a history of cancer who completed their initial therapy < 1 year before screening.
– Study participants with comorbidities or prior surgery precluding high fluid intake or leading to GI fluid losses
– Crohn’s disease, ulcerative colitis, short gut syndrome (e.g. ileostomy, bowel bypass surgery to treat obesity, small bowel resection), chronic diarrhea, or GI tract ostomy.
– History of malabsorptive (e.g., Roux-en-Y gastric bypass) or restrictive (e.g., sleeve gastrectomy) bariatric surgery procedures
– Congestive heart failure
– Lung disease with a home oxygen requirement
– Cirrhosis with ascites
– Renal transplant recipient
– Bedridden study participants


Holly Covert
(206) 616-5170

Additional Study Details

Full Study Title
Prevention of Urinary Stones with Hydration

Study ID: STUDY00002460
Start Date: 08/18/2017
End Date: 07/30/2021

Jonathan Harper, MD
Hunter Wessells, MD

Accepts Healthy Volunteers?

Study Site(s)

Northwest Kidney Stone Center

1536 N. 115th St. Suite 300
Seattle, Washington 98133

Seattle Children’s Hospital

4800 Sand Point Way NE
Seattle Washington 98105


Use the link below to send a message to the study coordinator, or call the number above to speak directly with a study representative.

I am interested in this research study.