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The ACE Exercise Study for Women

The ACE Exercise Study for Women

An active lifestyle reduces risk for breast cancer. The ACE study will investigate how a 45-minute bout of moderate exercise can affect the biology of the human body, which could explain how exercise reduces breast cancer risk.

If you are interested in participating you will be asked to fill out a survey either online or over the telephone to see if you are suitable for the study. If you qualify and are interested in participating, you will be scheduled for two clinic visits.

On the first visit, you will answer questions about your medical history and general health habits, have a brief physical exam, and an exercise test to see if you can tolerate moderate exercise and determine how fit you are. If you are eligible based on your test results, and would still like to participate, a computer program will assign you by chance to one of the following groups:

EXERCISE GROUP: Participants in this group will have a 45-minute bout of exercise on a stationary bike in the Fred Hutch exercise facility.

RESTING CONTROL GROUP: Participants in this group will sit for 45 minutes.

At the second visit, you will be asked to provide blood samples before and after the exercise bout or resting control period. We will also ask participants if they are willing to join an optional add-on study which involves a muscle biopsy before and after the exercise bout or resting control period.

How will you benefit?
All study participants will receive information about their study tests results, such as measures of blood pressure, glucose level and tests of fitness. At the end of the study, every participant will receive a 30 minute long session with an exercise physiologist who will take them through a sample aerobic + resistance training workout.

Participants who give blood samples before and after the exercise bout or resting control period will receive $25.

Participant Eligibility


Aged 18-75 years

Not using hormonal birth control (pre-menopausal women)

Not using hormone replacement therapy (post-menopausal women)

Able to exercise safely for 45 minutes at your fitness level

Resident in greater Seattle metropolitan area (King Country), Pierce or Snohomish Counties

Healthy (no history of diabetes or cancer (non-melanoma skin cancer is OK))

English speaker

Willing to be assigned by chance by a computer program to either the exercise or control group


Can visit our exercise center for two clinic visits at the Fred Hutchinson Cancer Research Center’s Prevention Center at South Lake Union.


Jude Warner
(888) 508-0395

Additional Study Details

Full Study Title
Acute Effects of Exercise in Women Study

Study ID: IR file # 8766
Start Date: 01/11/2019
End Date: 06/11/2021

Anne McTiernan (Principal Investigator)
Catherine Duggan (Co-Investigator)

Accepts Healthy Volunteers?

Study Site(s)

Fred Hutchinson Cancer Research Center

1100 Fairview Avenue North Fred Hutch Prevention Center
Seattle, Washington 98109



Use the link below to send a message to the study coordinator, or call the number above to speak directly with a study representative.

I am interested in this research study.