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The Purge-C Study

The Purge-C Study


The UW AIDS Clinical Trials Unit is looking for men and women with a new diagnosis of acute hepatitis C (HCV)–with OR without HIV–to volunteer for an investigational research study to evaluate if 4 weeks (instead of 8 to 12 weeks) of the drug glecaprevir/pibrentasvir (brand name Mavyret®) will cure HCV when given during acute infection.

Participant Eligibility

Be 18 years old or older.

You have acute HCV infection (confirmed within 6 months prior to entry), regardless of genotype.

If you are HIV-positive and if you are on ART, CD4 must be greater than 200 and your viral load undetectable.

If you are HIV positive and are not on ART, you must have no plans to start ART during study treatment.

If you are a woman, you must agree to contraception/birth control methods or provide documentation of sterilization and/or menopause.

Be willing to sign the consent after discussion with the research staff.


Cannot have known preexisting cirrhosis.

Cannot have chronic liver disease caused by something other than HCV.

Cannot be positive for the presence of Hepatitis A Virus or Hepatitis B Virus.

Cannot have a history of solid organ transplant.

Cannot have acute HIV infection.

Cannot be currently receiving ritonavir-boosted atazanavir, atazanavir (even if unboosted), rifampin, efavirenz, etravirine, didanosine, stavudine, ethinyl estradiol-containing medications, carbamazepine, oxcarbazepine, St. John’s wort.

Cannot have had any previous attempt at HCV treatment during this acute HCV infection episode, (within 24 weeks prior to entry).

Cannot be breastfeeding or pregnant.

Cannot have a known allergy/sensitivity or any hypersensitivity to components of study drug(s).


Clay Youngblood, RN
(206) 773-7129

Additional Study Details

Full Study Title
A Phase II Trial of Glecaprevir/Pibrentasvir Fixed-dose Combination Treatment for Acute Hepatitis C Virus Infection (PURGE-C)

Study ID: A-5380
Start Date: 06/07/2019
End Date: 06/07/2023

Rachel Bender Ignacio, MD Liz Duke, MD

Accepts Healthy Volunteers?

Study Site(s)

Harborview Medical Center

325 9th AVE 2nd floor of 2 West Clinics
Seattle, Washington 98104


Use the link below to send a message to the study coordinator, or call the number above to speak directly with a study representative.

I am interested in this research study.