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WEB Study (Weight Effects on Brain Health Study)

WEB Study (Weight Effects on Brain Health Study)

Study Description

WEB study is a longitudinal study that will examine changes that may occur in the brain following obesity treatment.

We are currently recruiting:

  1. People with BMI of 18.5-24.9 and who meet other study criteria
  2. People planning to have weight loss surgery with their health care team (study does not provide surgery)

Participants will have 5-6 in-person study visits at University of Washington in Seattle, Washington, South Lake Union research facilities over 18 months. Visits vary in length; screening takes 1-2 hours, 2 visits take 6-7 hours and 2-3 visits take 2-4 hours. For participants in the surgical group, all 5 visits take 2-4 hours. Study visit procedures include fasting and non-fasting blood draws, MRIs, DXA scans, complete questionnaires, and other research activities.

Participants may earn up to $475 for completing research procedures over the course of the study.


Eligibility will be determined by phone screening questions and confirmed following an in-person screening visit.

  • Age 21-64
  • Able to have an MRI
  • Available to participate in a study with several appointments over 18 months
  • Not currently using nicotine containing products daily
  • No severe food allergies
  • No history of weight loss surgery
  • Not taking insulin or other medications known to alter metabolism
  • No major medical conditions
  • No history of or current eating disorder
  • Not currently taking weight loss medications or currently enrolled in weight loss program




Additional Study Details

Full Study Title
A Cohort Study of Weight Loss and Gliosis

Study ID: 2978
Start Date: 02/01/2019
End Date: 06/04/2021

Ellen Schur, MD, MS
Mario Kratz, PhD, MS

Accepts Healthy Volunteers?

Study Site(s)

University of Washington

Republican St
Seattle, Washington 98109

Fred Hutchinson

Fairview Ave N
Seattle Washington 98109


Use the link below to send a message to the study coordinator, or call the number above to speak directly with a study representative.

I am interested in this research study.