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WEB Study (Weight Effects on Brain Health Study)

WEB Study (Weight Effects on Brain Health Study)

WEB study is a longitudinal study that will examine changes that may occur in the brain following obesity treatment. We are currently recruiting people who are eligible to participate in the behavioral weight loss intervention (BMI greater than 30, determined by phone screen).

All participants will have six in-person study visits at University of Washington in Seattle, Washington, South Lake Union research facilities over 18 months. Visits vary in length; some visits take about 3 hours and some take about 8 hours. Participants will have fasting and non-fasting blood draws, MRIs, DXA scans, complete questionnaires and other research activities. In addition, the behavioral weight loss group will participate in a six-month dietary intervention based at Fred Hutchinson.

Participants may earn up to $375 for completing research procedures over the course of the study.

Participant Eligibility

Eligibility will be determined by phone screening questions and confirmed following an in-person screening visit.

Age 25-64
Able to have an MRI
Available to participate in a study with several appointments over 18 months
Not currently using nicotine containing products daily
No severe food allergies
Not pregnant or breastfeeding
No history of weight loss surgery
Not taking insulin or other medications known to alter metabolism
No major medical conditions
No history of or current eating disorder
Not currently taking weight loss medications or currently enrolled in weight loss program


(206) 616-6360

Additional Study Details

Full Study Title
A Cohort Study of Weight Loss and Gliosis

Study ID: 2978
Start Date: 02/01/2019
End Date: 06/04/2021

Ellen Schur, MD, MS
Mario Kratz, PhD, MS

Accepts Healthy Volunteers?

Study Site(s)

University of Washington

Republican St
Seattle, Washington 98109

Fred Hutchinson

Fairview Ave N
Seattle Washington 98109


Use the link below to send a message to the study coordinator, or call the number above to speak directly with a study representative.

I am interested in this research study.