{"id":4705,"date":"2021-04-20T14:33:21","date_gmt":"2021-04-20T21:33:21","guid":{"rendered":"https:\/\/www.iths.org\/participate\/?p=4705"},"modified":"2021-04-22T11:33:50","modified_gmt":"2021-04-22T18:33:50","slug":"lift-ad","status":"publish","type":"post","link":"https:\/\/www.iths.org\/participate\/lift-ad\/","title":{"rendered":"LIFT AD"},"content":{"rendered":"
<\/div>\n

To evaluate the clinical efficacy of ATH-1017
\nTo determine the safety and tolerability of ATH-1017
\nTo evaluate the clinical efficacy of ATH-1017 separately on:
\n(1) cognition and
\n(2) clinical global impression of change
\nTo evaluate the effect of ATH-1017 on activities of daily living
\nTo determine the plasma pharmacokinetic (PK) profile of ATH-1017
\nTo evaluate the effect of ATH-1017 on behavioral changes
\nTo evaluate the effect of ATH-1017 on overall cognitive function
\nTo evaluate the effect of ATH-1017 on executive memory function
\nTo evaluate any effect of ATH-1017 on:
\n(1) caregiver burden
\n(2) healthcare resource utilization
\n(3) subject health-related quality of life<\/p>\n

This is a Phase 2 study<\/p>\n

Participant Eligibility<\/h3>\n

Males and females age 55 to 85, inclusive at time of signing informed consent
\nMild to moderate AD dementia
\nClinical diagnosis of dementia, due probably to AD
\nDocumented clinical decline within 12 months of evaluation
\nOnset of symptoms at least 12 months before evaluation – preferably participant's medical records but caregiver reports with examples are acceptable
\nReliable and capable support person\/caregiver who is willing to accept responsibility for supervising the treatment or, if required, administering study drug and assessing the condition of participant throughout the study
\nSupport person\/caregiver must see participant at least once daily for dose administration and\/or observation and have 4-6 hours of daytime contact with participant at least 4 days per week<\/p>\n

Contact<\/h3>\n

enroll
\n(142) 545-3040 x4<\/p>\n

<\/p>\n

Additional Study Details<\/h3>\n

Full Study Title<\/strong>
\nA Randomized, Placebo-Controlled, Double-Blind Study of ATH-1017 Treatment in Subjects with Mild to Moderate Alzheimer’s Disease
\n<\/span><\/p>\n

Study ID:<\/strong> 20202418<\/div>\n
ClinicalTrials.gov Link:<\/strong> NCT04488419<\/a><\/div>\n
<\/div>\n
Start Date:<\/strong> 07\/28\/2020<\/div>\n
End Date:<\/strong> 10\/31\/2022<\/div>\n
<\/div>\n

Investigator(s)<\/strong>
\nArifulla Khan
\n<\/span>
\nAccepts Healthy Volunteers?<\/strong>
\nNo<\/span><\/p>\n

Study Site(s)<\/strong> <\/p>\n

\n

Northwest Clinical Research Center<\/h4>\n

1951 152nd PL NE Suite 200
\nBellevue, Washington 98007<\/p><\/div>\n

\n

<\/h4>\n<\/p><\/div>\n
<\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

To evaluate the clinical efficacy of ATH-1017 To determine the safety and tolerability of ATH-1017 To evaluate the clinical efficacy of ATH-1017 separately on: (1) cognition and (2) clinical global impression of change To evaluate the effect of ATH-1017 on activities of daily living To…<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,17],"tags":[127,487,1220,343,129,1221],"class_list":["post-4705","post","type-post","status-publish","format-standard","hentry","category-brain-and-nervous-system","category-mental-health-and-behavior","tag-alzheimers","tag-alzheimers-disease","tag-ath-1017","tag-cognition","tag-dementia","tag-lift-ad"],"_links":{"self":[{"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/posts\/4705","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/comments?post=4705"}],"version-history":[{"count":1,"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/posts\/4705\/revisions"}],"predecessor-version":[{"id":4706,"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/posts\/4705\/revisions\/4706"}],"wp:attachment":[{"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/media?parent=4705"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/categories?post=4705"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/tags?post=4705"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}