{"id":4707,"date":"2021-04-20T15:52:30","date_gmt":"2021-04-20T22:52:30","guid":{"rendered":"https:\/\/www.iths.org\/participate\/?p=4707"},"modified":"2021-04-22T11:31:50","modified_gmt":"2021-04-22T18:31:50","slug":"avp-786-agitation","status":"publish","type":"post","link":"https:\/\/www.iths.org\/participate\/avp-786-agitation\/","title":{"rendered":"AVP-786 Agitation"},"content":{"rendered":"
<\/div>\n

To evaluate the efficacy, safety, and tolerability of AVP-786 compared to placebo, for the treatment of agitation in patients with dementia of the Alzheimer's type
\nTo evaluate the effects of AVP-786 compared to placebo on neuropsychiatric symptoms
\nTo evaluate the effects of AVP-786 compared to placebo on global assessments of severity and improvement of agitation
\nTo evaluate the effects of AVP-786 compared to placebo on measures of quality of life and resource utilization<\/p>\n

This is a Phase 3 study<\/p>\n

Participant Eligibility<\/h3>\n

Males and females 50 to 90 years of age inclusive, at the time of informed consent
\nDiagnosis of probable AD
\nOut patients or residents of assisted living facility can apply
\nHas a diagnosis of agitation
\nAgitation that interferes with daily routine
\nParticipants must have stable cardiac, pulmonary, hepatic, and renal function
\nMust have a caregiver that is willing to comply with study instructions
\nParticipant has dementia that is NOT from Parkinson's disease, substance induced, vascular, or frontotemporal types<\/p>\n

Contact<\/h3>\n

enroll
\n(425) 453-0404<\/p>\n

<\/p>\n

Additional Study Details<\/h3>\n

Full Study Title<\/strong>
\nA Phase 3, multicenter, randomized, double-blind, placebo-controlled, parallel-design study to assess the efficacy, safety, and tolerability of AVP-786 (deudextromethorphan hydrobromide [d6-DM]\/quinidine sulfate [Q]) for the treatment of agitation in patients with dementia of the Alzheimer’s type
\n<\/span><\/p>\n

Study ID:<\/strong> SSU00105289<\/div>\n
ClinicalTrials.gov Link:<\/strong> NCT03393520<\/a><\/div>\n
<\/div>\n
Start Date:<\/strong> 10\/13\/2017<\/div>\n
End Date:<\/strong> 07\/31\/2022<\/div>\n
<\/div>\n

Investigator(s)<\/strong>
\nArifulla Khan
\n<\/span>
\nAccepts Healthy Volunteers?<\/strong>
\nNo<\/span><\/p>\n

Study Site(s)<\/strong> <\/p>\n

\n

Northwest Clinical Research Center<\/h4>\n

1951 152nd Pl NE Suite 200
\nBellevue, Washington 98007<\/p><\/div>\n

\n

<\/h4>\n<\/p><\/div>\n
<\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

To evaluate the efficacy, safety, and tolerability of AVP-786 compared to placebo, for the treatment of agitation in patients with dementia of the Alzheimer's type To evaluate the effects of AVP-786 compared to placebo on neuropsychiatric symptoms To evaluate the effects of AVP-786 compared to…<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,17],"tags":[1225,127,1222,129,1223,1224],"class_list":["post-4707","post","type-post","status-publish","format-standard","hentry","category-brain-and-nervous-system","category-mental-health-and-behavior","tag-agitation","tag-alzheimers","tag-brain-disease","tag-dementia","tag-mental-disorders","tag-neurodegenerative-diseases"],"_links":{"self":[{"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/posts\/4707","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/comments?post=4707"}],"version-history":[{"count":1,"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/posts\/4707\/revisions"}],"predecessor-version":[{"id":4708,"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/posts\/4707\/revisions\/4708"}],"wp:attachment":[{"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/media?parent=4707"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/categories?post=4707"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/tags?post=4707"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}