{"id":5914,"date":"2025-07-30T06:35:35","date_gmt":"2025-07-30T13:35:35","guid":{"rendered":"https:\/\/www.iths.org\/participate\/?p=5914"},"modified":"2025-08-04T08:04:43","modified_gmt":"2025-08-04T15:04:43","slug":"attentional-indicators-of-cbt-non-response","status":"publish","type":"post","link":"https:\/\/www.iths.org\/participate\/attentional-indicators-of-cbt-non-response\/","title":{"rendered":"Attentional Indicators of CBT Non-Response"},"content":{"rendered":"

[vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern”][vc_column][vc_column_text css=””]<\/p>\n

<\/div>\n

Cognitive behavioral therapy (CBT) is the first-line psychological treatment for anxiety and obsessive compulsive (OC) disorders, yet approximately half of patients who receive CBT fail to achieve sustained clinical remission. Such failures are widespread but poorly studied and contribute to the escalating public health burden of anxiety. To date, no reliable biomarker capable of detecting CBT non-response exists. In this study, we seek to fill this gap by collecting a battery of clinical, behavioral, self-report, and neural measurements before, during, and after CBT in a large cohort of patients with Social Anxiety Disorder (SAD), Body Dysmorphic Disorder (BDD), and healthy controls. We will first examine the reliability and construct validity of a biomarker in a subgroup of 50 patients and 50 matched healthy controls. Next, we will provide 12 weeks of standard CBT for 110 patients with SAD and BDD. Neuroimaging data will be acquired at baseline, week 6, and post-treatment to assess changes in functional connectivity throughout treatment and examine their relation to treatment response. Thus, this study will reveal potential mechanistic indicators of CBT non-response that can guide treatment selection and planning.<\/p>\n

A link to our study website can be found here: https:\/\/uwifocus.com\/<\/a><\/a><\/p>\n

Participant Eligibility<\/h3>\n

\u2013 Age 18-45
\n\u2013 No fMRI contraindications (non-removable metal in body such as copper IUD or cardiac pacemaker, not pregnant, etc)
\n\u2013 Fluent in English and willing to provide informed consent
\n\u2013 No lifetime history of manic or hypomanic episode, psychotic symptoms, traumatic brain injury,
\nneurological disorder, pervasive developmental disorder, or attention deficit-hyperactivity disorder
\n\u2013 Must be living within the Greater Seattle area and be able to commute to the University of Washington for regular study visits
\n\u2013 Treatment seeking individuals who have significant appearance concerns AND\/OR significant fear of social situations<\/p>\n

Contact<\/h3>\n

Randhara Kotuwelle
\n(206) 221-1278<\/p>\n

\n

Additional Study Details<\/h3>\n

Full Study Title<\/strong>
\nEarly Attentional Indicators of Cognitive Behavioral Therapy Non-Response
\n<\/span><\/p>\n

Study ID:<\/strong> STUDY00019785<\/div>\n
ClinicalTrials.gov Link:<\/strong><\/div>\n
<\/div>\n
Start Date:<\/strong> 04\/01\/2024<\/div>\n
End Date:<\/strong> 03\/31\/2029<\/div>\n
<\/div>\n

Investigator(s)<\/strong>
\nAngela Fang, PhD (Principal Investigator)
\nJamie Feusner, MD (Co-Investigator)
\nNoah Benson, PhD (Co-Investigator)
\nLori Zellner, PhD (Co-Investigator)
\n<\/span>
\nAccepts Healthy Volunteers?<\/strong>
\nYes<\/span><\/p>\n

Study Site(s)<\/strong><\/p>\n

\n

University of Washington – Kincaid Hall<\/h4>\n

3751 W Stevens Way NE
\nSeattle, Washington 98195<\/p>\n<\/div>\n

\n

<\/h4>\n<\/div>\n
<\/div>\n

<\/div>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern”][vc_column][vc_column_text css=””] Cognitive behavioral therapy (CBT) is the first-line psychological treatment for anxiety and obsessive compulsive (OC) disorders, yet approximately half of patients who receive CBT fail to achieve sustained clinical remission. Such failures are widespread but poorly…<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[1664,1158,1457,116],"class_list":["post-5914","post","type-post","status-publish","format-standard","hentry","category-brain-and-nervous-system","tag-body-dysmorphic-disorder","tag-cognitive-behavioral-therapy","tag-social-anxiety-disorder","tag-therapy"],"_links":{"self":[{"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/posts\/5914","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/comments?post=5914"}],"version-history":[{"count":3,"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/posts\/5914\/revisions"}],"predecessor-version":[{"id":5923,"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/posts\/5914\/revisions\/5923"}],"wp:attachment":[{"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/media?parent=5914"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/categories?post=5914"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iths.org\/participate\/wp-json\/wp\/v2\/tags?post=5914"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}