Population Health Resource Directory

Terrance Kavanagh

tkavanagh.jpg

Glutathione (GSH) is an important endogenous antioxidant that has roles in free radical scavenging, protecting against reactive oxygen/nitrogen species and in the metabolism/excretion of xenobiotics. Our laboratory has established in vitro and in vivo transgenic mouse models of altered glutathione (GSH) synthesis. We are using these mice to investigate the effects of altered GSH synthesis on susceptibility to various exposures including air pollutants, engineered nanomaterials, and various drugs and environmental chemicals. We are also interested in the role of GSH synthesis in individual susceptibility of humans to free radical and toxicant-mediated injury. We are conducting studies to determine the effects of genetically altered GSH synthesis on cellular susceptibility to toxicant-induced DNA, protein and lipid damage, cell signaling and apoptosis. We are also interested in the factors that regulate the expression of GSH related genes in humans, rodents and other species.

Multiple sources of air pollutants such as industrial processes, automobile traffic, forest fires or indoor cooking fires continue to plague human society, resulting in adverse effects on the respiratory system, the cardiovascular system, the central nervous system, and on growth and development. Working with Drs. Joel Kaufman and Michael Rosenfeld, we are investigating the adverse effects of diesel exhaust and particulate matter on lung function, vascular reactivity and the development and stability of atherosclerotic lesions in mice. This project is employing a model of enhanced sensitivity to oxidative stress (Gclm null mice), genetically diverse mice (the Collaborative Cross mouse strains), as well as mouse and human vascular endothelial cells and macrophages to examine the biochemical and cellular mechanisms underlying the adverse cardiovascular outcomes associated with exposure to air pollution.

Nanotechnology holds promise for advancement in many disciplines, including electronics, optronics, energy, transportation, biomedicine and other sectors. Because of their small size and inherent high surface area/reactivity, or because the materials used to synthesize nanoparticles can be toxic, we have been interested in helping to define which physical and chemical characteristics of engineered nanomaterials (ENMs) predispose to toxicity and adverse health outcomes. Together with Drs. David Eaton, Elaine Faustman, Michael Yost (DEOHS), William Parks (Pulmonary Medicine and UW Center for Lung Biology), Xiaohu Gao (Bioengineering) and François Baneyx (Chemical Engineering and UW Center for Nanotechnology), we are participants in the NIEHS Centers for Nanotechnology Health Implications Research (NCNHIR) Consortium. This program is using in vitro toxicology, in vivo toxicology (including systems toxicology/mouse genetics), and risk assessment approaches to investigate the adverse effects of ENMs with the goals of elucidating the mechanisms by which they cause toxicity and inflammation, and using this mechanistic information to facilitate the design of safer ENMs.

In addition to the above projects, Dr. Kavanagh is Deputy Director of the Center for Ecogenetics and Environmental Health (CEEH), and oversees its Pilot Projects Program, and the CEEH Technology Access Unit. He also directs the CEEH Analytical Cytology Core. This facility houses two fluorescence activated cell sorters, a spectral imaging microscope, and a Nipkow-disk confocal microscope, which are useful for multi-parameter quantitative fluorescence measurements on cells and tissues.

Home Campus, School, or College
School of Public Health
Population Health Focus Keywords
Built Environment Impacts, Environmental Health, Technology and Health, Non-Infectious Disease
Field of Study
Public Health, Technology
Key Populations
Adult
In what countries of the world does your research take place?

USA

Home Campus, School, or College
Ishem.jpg
Linda’s research focus is on examining the causes of urban neighborhood decline and the ine...
Durran_Bonnie.jpg
Bonnie Duran Dr.PH (mixed race Opelousas/Coushatta descendent) is an associate professor in the S...
Bekemeier_Betty.jpg
Betty Bekemeier is associate professor at the University of Washington (UW) School of Nursing and...
gregory-roth.jpg
Gregory A. Roth, MD, MPH, is an Assistant Professor at the Institute for Health Metrics and Evalu...
drain.jpg
Paul Drain, MD, MPH, is Assistant Professor in the Departments of Global Health, Medicine (Infect...
nurius_0.png
Dr. Paula Nurius studies processes and effects of stress and trauma focusing on vulnerable and so...
Udell-Wadiya_cropped.jpg
Wadiya Udell, PhD, is an Associate Professor of Community Psychology in the Interdisciplinary Art...
W-Logo_Purple_Hex.png
Fuller is Professor Emeritus, Biomedical and Health Informatics, School of Medicine and Informat...
Kari.jpg
My research and scholarship centers on the critical study of social inequality, focusing on the r...
Lichty.JPG
Through multiple strands of research that mix paradigms, media, and methods, I seek to identify h...
Katryna-McCoy.jpg
Dr. McCoy’s scholarship is focused on the factors that influence the management of HIV as a chron...
Nora-Kenworthy.jpg
My work sits at the intersections of medical anthropology, public health, and politics. I have be...
Mabel-Ezeonwu.jpg
Dr. Ezeonwu’s scholarship extends into the national and global policy arena, and integrates...
Jody-Early.jpg
Jody’s research, teaching, and community work have been greatly influenced by Paulo Freire’s crit...
Dan-Bustillos.jpg
As a medical humanist, health lawyer, public health policymaker and bioethicist, Dr. Bustillos ha...
carlisle.jpg
My primary research focus lies within social epidemiology and the social demography of health dis...
Selina.jpg
Selina’s scholarship centers on social justice and the effects of social determinants of health. ...
portrait.tway.jpg
Thaisa Way is an urban landscape historian teaching and researching history, theory, and design i...
BarnesChris.jpg
I have three main areas of interest in my research pursuits: (1) Fatigue in organizations, focusi...
uw-logo.png
I am a social demographer with broad interests in race-ethnicity, inequality, fertility, and fami...
hill_karl_0.png
Dr. Hill has worked at the Social Development Research Group since 1994. He is a social developme...
jonno.jpg
I develop spatial methods for health data, and work on studies for both infectious and non-infect...
zuntres.jpg
I am Professor in the Departments of Neurology and Global Health, with Adjunct appointments in th...
Dieleman-Jospeh.jpg
I lead the Financial Resources for Health research team at the Institute for Health Metrics and E...
Amy-Snover-528x528.jpg
Amy K. Snover is the Associate Dean for Applied Research in the College of the Environment and Af...
Showing 51 - 75 of 304 results