My main research focus is the etiology, prevention and early detection of esophageal adenocarcinoma and other cancers of the upper aerodigestive tract, which I have been investigating in observational studies for over 30 years.
I have extensive experience in directing and participating in collaborative projects across multiple disciplines internationally. In 2005 I co-founded the international Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON), and continue to chair its Steering Committee. I have been communicating PI of a genome-wide association study of Barrett’s esophagus and esophageal adenocarcinoma, involving 15 sites (over 8,000 participants) within BEACON. I am also co-investigator on a long-standing P01 and a Provocative Question grant which involve whole genome and whole exome sequencing, respectively, and serve on the Esophageal Cancer Analysis Working Group for NCI’s Cancer Genome Atlas program.
US, western Europe + UK, Australia