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Immunologic Monitoring Laboratory (IML), University of Washington

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Tumor Vaccine Group, University of Washington, 850 Republican St, Seattle, WA 98109
850 Republican Street Seattle Washington 98109 US
(206) 534-8557(206) 534-8557

We now know that human tumors are immunogenic and have identified a variety of proteins that act as tumor antigens, i.e. stimulate an immune response. We have a more detailed understanding of T-cell-antigen recognition and the character of peptide fragments presented in MHC molecules. Finally, mechanisms of tumor immune escape are much better understood, such as the role tolerance plays in dampening the tumor specific immune response and the importance of appropriate antigen presenting cells, such as dendritic cells, in initial immune stimulation. Reported trials of cancer immunotherapy, including vaccines, are demonstrating the ability to elicit detectable tumor specific immunity in cancer patients. There are no standard immunologic monitoring methods that will allow comparison of immune based clinical strategies between labs or will even allow accurate assessment of the immunogenicity of a particular approach. Standardization and development of reproducible and clinical grade immunologic assays to determine the magnitude of tumor specific immune responses generated in the context of clinical trials of cancer immunotherapy is an area of research in the TVG.

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Institution
University of Washington
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Histology and Imaging Core, UW Medicine at SLU, Room N310, 850 Republican St., Seattle, WA 98109 0 mi
(206) 685-6517(206) 685-6517
We have extensive experience collaborating with investigators across a broad range of research an...
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Quellos High Throughput Screening Core, Institute for Stem Cell and Regenerative Medicine, 850 Republican St., Seattle, WA 98109 0 mi
(206) 616-3115(206) 616-3115
The Quellos High Throughput Screening (HTS) Core specializes in Functional Genomics as well as Dr...
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Institute for Stem Cell and Regenerative Medicine, UW Medicine Research, 850 Republican St, Seattle, WA 98109 0 mi
(206) 685-1954(206) 685-1954
The University of Washington Institute for Stem Cell and Regenerative Medicine (ISCRM) is committ...
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Northwest Metabolomics Research Center, South Lake Union, 850 Republican Street, Seattle, WA 98109 0 mi
(206) 685-4753(206) 685-4753
Welcome to the Northwest Metabolomics Research Center (NW-MRC). The NW-MRC is located at the Univ...
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UW Proteomics Resource, University of Washington at South Lake Union, 850 Republican St, Seattle, WA 98109 0 mi
(206) 616-0659(206) 616-0659
The University of Washington’s Proteomics Resource (UWPR) is a proteomics facility whose mi...
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Data and Safety Monitoring, Institute of Translational Health Sciences, 850 Republican St, Seattle, WA 98109 0 mi
(206) 221-1234(206) 221-1234
National Institutes of Health (NIH) policy requires that investigators include a general descript...
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Research Coordination Support Services, Institute of Translational Health Sciences, 850 Republican St., Seattle, WA 98109 0 mi
(206) 221-1234(206) 221-1234
The ITHS Research Coordination Center (RCC) provides investigators with trained research support ...
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815 Mercer Street, Seattle, WA 98109, United States 0.02 mi
(206) 543-3061(206) 543-3061
The Bio-Molecular Imaging Center’s (BMIC) mission is to develop novel imaging techniques for anat...
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Veterinary Diagnostic Laboratory, 815 Mercer St. Room 310N, Seattle, WA 98195 0.02 mi
(206) 685-3040(206) 685-3040
The University of Washington Veterinary Diagnostic Laboratory is staffed with veterinary patholog...
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South Lake Union Confocal Facility, 815 Mercer St, Seattle, WA 98109 0.02 mi
ronse@uw.eduronse@uw.edu
A Zeiss Confocal Microscope; model LSM510Meta is available to South Lake Union labs. The instrume...
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UW Medicine Proteomics Lab, South Lake Union, 815 Mercer St, Seattle, WA 98109 0.02 mi
(206) 616-0659(206) 616-0659
Our current focus is to provide mass spectrometry resources and computational support for the gre...
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UW SLU, 815 Mercer St, Seattle, WA 0.02 mi
The overall goals of the QFPC are to provide the powerful tools of modern mass spectrometry and c...
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VTMC, UW SLU, 815 Mercer St, Seattle, WA 98109 0.02 mi
(206) 543-1681(206) 543-1681
The overall goal of the VTMC is to provide DRC affiliate investigators with state-of-the-art vect...
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SLU Lab Services, Brotman Building, 815 Republican Street, Seattle, WA 98109 0.05 mi
(206) 685-2720(206) 685-2720
The SLU Lab Services is located in Room B56 of the Brotman Building. The center provides a variet...
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Diabetes and Obesity Center of Excellence, UW Medicine Research, Republican St., Seattle, WA 98109 0.13 mi
(206) 221-0551(206) 221-0551
The Diabetes and Obesity Center of Excellence (DOCE), located at the South Lake Union research ca...
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Institute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109 0.16 mi
(206) 732-1200(206) 732-1200
The Institute for Systems Biology is a premier, nonprofit research organization based in Seattle,...
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Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109 0.17 mi
(206) 732-1200(206) 732-1200
The Image and Cytometry Core Facility at ISB offers microscopy and cytometry tools for cell purif...
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Center for Infectious Disease Research, 307 Westlake Ave N, Suite 500, Seattle, WA 98109 0.2 mi
(206) 256-7200(206) 256-7200
We believe that targeted research is the first step toward conquering any disease. Our world-clas...
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3T Whole-Body MRI, South Lake Union Bio-Medical Imaging Center, Seattle, WA 98109 0.42 mi
(206) 616-1697(206) 616-1697
3T Whole-Body MRI available at UW South Lake Union Bio-Medical Imaging Center.
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IIC, UW SLU, 815 Mercer Seattle, WA 98109 0.42 mi
(206) 221-5275(206) 221-5275
The overall goals of the IIC are to provide state-of-the-art flow cytometry analysis of the cellu...
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Cite ITHSThe Institute is supported by grants UL1 TR002319, KL2 TR002317, and TL1 TR002318 from the NIH National Center for Advancing Translational Sciences through the Clinical and Translational Science Awards Program (CTSA).

Please help us continue to support your research by citing our grant number(s) in publications we supported.