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Immunologic Monitoring Laboratory (IML), University of Washington

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Tumor Vaccine Group, University of Washington, 850 Republican St, Seattle, WA 98109
850 Republican Street Seattle Washington 98109 US
(206) 534-8557(206) 534-8557

We now know that human tumors are immunogenic and have identified a variety of proteins that act as tumor antigens, i.e. stimulate an immune response. We have a more detailed understanding of T-cell-antigen recognition and the character of peptide fragments presented in MHC molecules. Finally, mechanisms of tumor immune escape are much better understood, such as the role tolerance plays in dampening the tumor specific immune response and the importance of appropriate antigen presenting cells, such as dendritic cells, in initial immune stimulation. Reported trials of cancer immunotherapy, including vaccines, are demonstrating the ability to elicit detectable tumor specific immunity in cancer patients. There are no standard immunologic monitoring methods that will allow comparison of immune based clinical strategies between labs or will even allow accurate assessment of the immunogenicity of a particular approach. Standardization and development of reproducible and clinical grade immunologic assays to determine the magnitude of tumor specific immune responses generated in the context of clinical trials of cancer immunotherapy is an area of research in the TVG.

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Institution
University of Washington
Institution
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Histology and Imaging Core, UW Medicine at SLU, Room N310, 850 Republican St., Seattle, WA 98109 0 mi
(206) 685-6517(206) 685-6517
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Quellos High Throughput Screening Core, Institute for Stem Cell and Regenerative Medicine, 850 Republican St., Seattle, WA 98109 0 mi
(206) 616-3115(206) 616-3115
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Institute for Stem Cell and Regenerative Medicine, UW Medicine Research, 850 Republican St, Seattle, WA 98109 0 mi
(206) 685-1954(206) 685-1954
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Northwest Metabolomics Research Center, South Lake Union, 850 Republican Street, Seattle, WA 98109 0 mi
(206) 685-4753(206) 685-4753
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UW Proteomics Resource, University of Washington at South Lake Union, 850 Republican St, Seattle, WA 98109 0 mi
(206) 616-0659(206) 616-0659
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Data and Safety Monitoring, Institute of Translational Health Sciences, 850 Republican St, Seattle, WA 98109 0 mi
(206) 221-1234(206) 221-1234
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Research Coordination Support Services, Institute of Translational Health Sciences, 850 Republican St., Seattle, WA 98109 0 mi
(206) 221-1234(206) 221-1234
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815 Mercer Street, Seattle, WA 98109, United States 0.02 mi
(206) 543-3061(206) 543-3061
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Veterinary Diagnostic Laboratory, 815 Mercer St. Room 310N, Seattle, WA 98195 0.02 mi
(206) 685-3040(206) 685-3040
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South Lake Union Confocal Facility, 815 Mercer St, Seattle, WA 98109 0.02 mi
ronse@uw.eduronse@uw.edu
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UW Medicine Proteomics Lab, South Lake Union, 815 Mercer St, Seattle, WA 98109 0.02 mi
(206) 616-0659(206) 616-0659
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SLU Lab Services, Brotman Building, 815 Republican Street, Seattle, WA 98109 0.05 mi
(206) 685-2720(206) 685-2720
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Diabetes and Obesity Center of Excellence, UW Medicine Research, Republican St., Seattle, WA 98109 0.13 mi
(206) 221-0551(206) 221-0551
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Institute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109 0.16 mi
(206) 732-1200(206) 732-1200
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Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109 0.17 mi
(206) 732-1200(206) 732-1200
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Center for Infectious Disease Research, 307 Westlake Ave N, Suite 500, Seattle, WA 98109 0.2 mi
(206) 256-7200(206) 256-7200
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3T Whole-Body MRI, South Lake Union Bio-Medical Imaging Center, Seattle, WA 98109 0.42 mi
(206) 616-1697(206) 616-1697
Showing 1 - 20 of 167 results

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Cite ITHSThe Institute is supported by grants UL1 TR002319, KL2 TR002317, and TL1 TR002318 from the NIH National Center for Advancing Translational Sciences through the Clinical and Translational Science Awards Program (CTSA).

Please help us continue to support your research by citing our grant number(s) in publications we supported.