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ADAPT study hopes to learn if body and brain changes can predict why weight loss stops. This study requires in-person and remote visits over 18 months at UW South Lake Union and Fred Hutchinson.1. Screening visit in-person: ~2 hours at UW SLU*remote tasks leading up to enrollment over 7 days before Baseline visit2. Baseline visit day 1: ~6 hours at UW SLU3. Baseline visit day 2: ~2 hours at Fred Hutchinson*remote assessments about 6-7 times over 18-monthsPayment up to $300Some participants may be invited to have additional visits. The visits are similar to Baseline day 1 and 2. Up to $250 of additional payment will be given for these visits.Study procedures: blood draws, MRIs, DXA scan, dietary intake evaluation, questionnaires and eating a snack. At Fred Hutchinson participants will have muscle and fat tissue biopsy and indirect calorimetry (breathing test).You will also participate in a 24-week group weight loss program by videoconference with Fred Hutchinson staff. Most people lose between 5-10% of their body weight in a similar program.========================If you are interested in this study,please fill out this survey:https://redcap.link/ADAPT========================

Participant Eligibility

-Age 18-60
-BMI 30-50 kg/m2
-Willing to attend in-person study visits and complete tasks remotely over 18 months
-Willing to participate in remote weight loss program on weekdays over 6-months
-No major medical conditions
-Not currently trying to lose weight
-Willing to have fat and muscle biopsies, MRIs, DXA scans and blood draws
-Screening will determine study eligibility


ADAPT Study Team

Additional Study Details

Full Study Title
Assessing Diet, Appetite and Physiology Throughout Weight Loss

Study ID: STUDY00017667
Start Date: 04/28/2023
End Date: 12/01/2025

Marian Neuhouser, PhD, RD
Ellen Schur, MD, MS
Jenny Tong, MD, MPH

Accepts Healthy Volunteers?

Study Site(s)

University of Washington

750 Republican St
Seattle, Washington 98109

Fred Hutchinson

1100 Fairview Ave N
Seattle Washington 98109


Use the link below to send a message to the study coordinator, or call the number above to speak directly with a study representative.

I am interested in this research study.