Brain & Nervous System

This protocol includes studies on how aging affects the control and coordination of speech production. Various hypotheses are being investigated in our laboratory with the common aim of improving our understanding of the processes and mechanisms underlying normal and disordered speech. The common procedure across…

The University of Washington SPEAC Lab is inviting individuals who have experienced changes in their thinking and memory; and have been diagnosed with, or are concerned about Mild Cognitive Impairment or early-stage dementia. This study involves answering survey questions about their experiences communicating with other…

The University of Washington SPEAC Lab is inviting individuals who have been diagnosed with spasmodic dysphonia (also known as laryngeal dystonia) to answer survey questions about their communication experiences. We ask participants to nominate at least one family member, friend, or coworker to also answer…

The University of Washington SPEAC Lab is inviting individuals who have experienced changes to their speech and/or voice due to Parkinson’s disease to answer survey questions about their communication experiences. We ask participants to nominate at least one family member, friend, or coworker to also…

The EN 21-01 study is testing a new investigational medication, called NRD135S.E1, to see if it is helpful and safe for patients with painful diabetic peripheral neuropathy. NRD135S.E1 showed a decrease in pain after 3 weeks of study treatment when compared to a placebo in…

The main question the WYE study is exploring: Does the brain change after short term diet changes and can MRI detect these changes?Participants will have an in-person screening visit, then 5 in-person study visits at UW SLU in the morning over a 2 week period…

This is a multicenter longitudinal study that aims to validate a set of measures that were previously identified as promising candidate biomarkers and/or sensitive and reliable objective measures of social function in ASD for potential use in clinical trials. The confirmation study will repeat the…

SPARK is a free, online study with a simple mission: to speed up research and advance the understanding of autism. SPARK study is now the largest autism research study in the world, with over 275,000 study participants. An important part of SPARK is the collection of…

The primary objective of this study is to assess the efficacy of botulinum toxin injections to the upper limb muscles for essential tremor. In the first part of the study, only one arm will be injected with either botulinum toxin or placebo and then followed…

People with multiple sclerosis (MS) often have problems with fatigue. For some people, fatigue is their most debilitating symptom of MS. Yet, many of the available treatments provide inadequate relief for fatigue. Past research has found that training in self-hypnosis is linked to reduced fatigue…

To evaluate the efficacy, safety, and tolerability of AVP-786 compared to placebo, for the treatment of agitation in patients with dementia of the Alzheimer's type To evaluate the effects of AVP-786 compared to placebo on neuropsychiatric symptoms To evaluate the effects of AVP-786 compared to…

To evaluate the clinical efficacy of ATH-1017 To determine the safety and tolerability of ATH-1017 To evaluate the clinical efficacy of ATH-1017 separately on: (1) cognition and (2) clinical global impression of change To evaluate the effect of ATH-1017 on activities of daily living To…

The purpose of this study is to understand whether metformin (Glucophage® XR), a medication used for diabetes treatment and prevention, can prevent a decline in memory and thinking abilities for people who are already having mild memory problems. At the first study visit you would have…

BASIC2 is studying ways to help overweight kids and their parents reach and maintain a healthy weight. This longitudinal study is trying to learn if the study medicine combined with family-based treatment helps kids better manage their weight. You and your child would attend free…

The Cognition and Cortical Dynamics Laboratory at the University of Washington is recruiting healthy English-Chinese bilingual participants for a study that occurs over 7 weeks where individuals will be tested on a battery of language and cognitive measures, followed by 6 weeks of computer programming…

The purpose of this pilot study is to record the daily human activities, and to develop predictive models of physical activity. We hope this study will enable researchers to test and validate new technologies that may subsequently be used to study and inform researchers and…

Ambulatory children with cerebral palsy (CP) walk predominately in low intensity stride rates with little variability, thus limiting their walking activity and ability to participate in daily life. In contrast, typically developing (TD) children engage in short bursts of intense walking activity interspersed with varying…

Ambulatory children with cerebral palsy (CP) experience walking limitations which negatively influence their ability to physically participate in day to day life. The investigators propose that impaired muscle power generation is the key limiting factor affecting walking activity and participation. This proposal represents a combined…

Ambulatory children with cerebral palsy (CP) demonstrate altered lower limb biomechanical alignment in walking (e.g. excessive hip/knee flexion or equinus during stance) and experience walking activity limitations that negatively influence their ability to participate in day to day life. Ankle Foot Orthoses (AFO) are a…

The University of Washington Institute for Language and Brain Sciences is recruiting hard of hearing infants between 2 and 12 months of age who have a mild-to-moderate hearing loss. This study looks at the effects of hearing loss on early brain development and learning. The…

The Infant Brain Imaging Study, or IBIS, is a research study of brain development in infants and children. The IBIS Network is a consortium of researchers across North America, including the University of Washington, that work together to discover early changes in brain development of…

The Infant Brain Imaging Study, or IBIS, is a research study of brain development in infants and children with autism. The IBIS Network is a consortium of researchers across North America, including the University of Washington Autism Center, that work together to discover early changes…

University of Washington researchers, led by Drs. Natalia Kleinhans and Stephen Dager, are recruiting pregnant participants who have not used marijuana during their first trimester and those who have used marijuana during their first trimester for a new study of prenatal development. Participants are not...

Our team is the NeuDLL (Neurodevelopmental Disorders Language & Learning) Lab in the UW Speech & Hearing Department. We are seeking families to participate in research related to spoken language in children with and without developmental disorders. Our current study focuses on how children learn…

The purpose of this study is to identify possible brain or spinal cord differences in participants with ALS compared to participants without ALS. Research shows that 90 to 95 percent of ALS cases occur at random, with only 5-10 percent of ALS cases being inherited….

We are learning more and more about the risks for Alzheimer’s disease every year, and that includes learning what foods are best at promoting brain health. It might be more complicated than ‘this food is good or bad.’ Dr. Angela Hanson, a geriatric physician at…

The GET Smart study is looking at whether exercise has an impact on cognition in people with MS. Researchers at the University of Washington are studying exercise because other studies have shown that exercise can help cognition in other non-MS populations. However, currently we do…

This protocol includes studies of the control and coordination of speech production. Various hypotheses are being investigated in our laboratory with the common aim of improving our understanding of the processes and mechanisms underlying normal and disordered speech. The common procedure across these studies consists…