Brain & Nervous System

To evaluate the efficacy, safety, and tolerability of AVP-786 compared to placebo, for the treatment of agitation in patients with dementia of the Alzheimer's type To evaluate the effects of AVP-786 compared to placebo on neuropsychiatric symptoms To evaluate the effects of AVP-786 compared to…

To evaluate the clinical efficacy of ATH-1017 To determine the safety and tolerability of ATH-1017 To evaluate the clinical efficacy of ATH-1017 separately on: (1) cognition and (2) clinical global impression of change To evaluate the effect of ATH-1017 on activities of daily living To…

To assess the effect of donanemab versus placebo on clinical progression in participants with early symptomatic AD with demonstrated presence of tau pathology To assess the effect of donanemab versus placebo on clinical progression of participants with early symptomatic AD To assess the effect of…

The purpose of this study is to understand whether metformin (Glucophage® XR), a medication used for diabetes treatment and prevention, can prevent a decline in memory and thinking abilities for people who are already having mild memory problems. At the first study visit you would have…

Researchers at Seattle Children’s want to learn about the impact of COVID-19 on the emotional health of children and teens. This research study is for kids and parents. If you decide to take part in the research study, you and your child would: • Fill…

Many individuals with MS suffer from fatigue, which can be their most disabling symptom. Research is needed to figure out how to match treatments to individual patients so that the treatments will have the greatest effect. The purpose of this clinical trial is to compare…

Recruiting parents and guardians of children in High School who recently experienced a traumatic brain injury or concussion. We are working to develop an innovative program that aims to improve student outcomes while the student gradually returns to schoolwork after the brain injury. Participation in…

BASIC2 is studying ways to help overweight kids and their parents reach and maintain a healthy weight. This longitudinal study is trying to learn if the study medicine combined with family-based treatment helps kids better manage their weight. You and your child would attend free…

The Cognition and Cortical Dynamics Laboratory at the University of Washington is recruiting healthy English-Chinese bilingual participants for a study that occurs over 7 weeks where individuals will be tested on a battery of language and cognitive measures, followed by 6 weeks of computer programming…

BEAM study is a longitudinal study that is trying to learn more about the role the brain plays in appetite and body weight changes in children. We are recruiting healthy children who are willing to participate in the study activities. All participants will have one…

The purpose of this pilot study is to record the daily human activities, and to develop predictive models of physical activity. We hope this study will enable researchers to test and validate new technologies that may subsequently be used to study and inform researchers and…

What if we could detect whether or not you’re getting sick just from information you already collect on your smartphone? The University of Washington is recruiting 25,000 volunteers age 19 and older to help us see if information from your smartphone can help us detect…

Aging with Pride: IDEA is recruiting adults aged 50 and older with memory loss or other dementia symptoms and their care partners. Either the person with memory loss and/or the care partner needs to be LGBTQ. The participant with memory loss and their care partner…

This protocol includes studies investigating the mechanisms involved in the integration of sensory information and central motor commands for the control of speech. Various hypotheses are being investigated with the common aim of improving our understanding of the processes and mechanisms underlying normal and disordered…

Ambulatory children with cerebral palsy (CP) walk predominately in low intensity stride rates with little variability, thus limiting their walking activity and ability to participate in daily life. In contrast, typically developing (TD) children engage in short bursts of intense walking activity interspersed with varying…

Ambulatory children with cerebral palsy (CP) experience walking limitations which negatively influence their ability to physically participate in day to day life. The investigators propose that impaired muscle power generation is the key limiting factor affecting walking activity and participation. This proposal represents a combined…

Ambulatory children with cerebral palsy (CP) demonstrate altered lower limb biomechanical alignment in walking (e.g. excessive hip/knee flexion or equinus during stance) and experience walking activity limitations that negatively influence their ability to participate in day to day life. Ankle Foot Orthoses (AFO) are a…

The University of Washington Institute for Language and Brain Sciences is recruiting hard of hearing infants between 2 and 12 months of age who have a mild-to-moderate hearing loss. This study looks at the effects of hearing loss on early brain development and learning. The…

The Infant Brain Imaging Study, or IBIS, is a research study of brain development in infants and children. The IBIS Network is a consortium of researchers across North America, including the University of Washington, that work together to discover early changes in brain development of…

The Infant Brain Imaging Study, or IBIS, is a research study of brain development in infants and children with autism. The IBIS Network is a consortium of researchers across North America, including the University of Washington Autism Center, that work together to discover early changes…

University of Washington researchers, led by Natalia Kleinhans, are recruiting pregnant participants who have not used marijuana during their first trimester and those who have used marijuana during their first trimester for a new study of prenatal development. Participants are not required to use marijuana…

The University of Washington is conducting a research study called the Estia Study to see if playing “brain games” can improve mood, memory, and concentration in adults between 45 and 75 years of age who have symptoms of depression. If you qualify for this study,…

WEB study is a longitudinal study that will examine changes that may occur in the brain following obesity treatment. We are currently recruiting: 1. people who are eligible to participate in the behavioral weight loss intervention (BMI greater than 30, determined by phone screen) 2….

Our team is the NeuDLL (Neurodevelopmental Disorders Language & Learning) Lab in the UW Speech & Hearing Department. We are seeking families to participate in research related to spoken language in children with and without developmental disorders. Our current study focuses on how children learn…

Chronic pain is one of the most prevalent, disabling and persistent symptoms associated with multiple sclerosis (MS). Despite a high level of healthcare utilization for pain, about half of adults with MS continue to experience moderate or severe persistent pain. Chronic pain has been linked…

The purpose of this study is to identify possible brain or spinal cord differences in participants with ALS compared to participants without ALS. Research shows that 90 to 95 percent of ALS cases occur at random, with only 5-10 percent of ALS cases being inherited….

We are learning more and more about the risks for Alzheimer’s disease every year, and that includes learning what foods are best at promoting brain health. It might be more complicated than ‘this food is good or bad.’ Dr. Angela Hanson, a geriatric physician at…

The GET Smart study is looking at whether exercise has an impact on cognition in people with MS. Researchers at the University of Washington are studying exercise because other studies have shown that exercise can help cognition in other non-MS populations. However, currently we do…

This protocol includes studies of the control and coordination of speech production. Various hypotheses are being investigated in our laboratory with the common aim of improving our understanding of the processes and mechanisms underlying normal and disordered speech. The common procedure across these studies consists…