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Immune response and genetics of infection among SE Asians

Immune response and genetics of infection among SE Asians

Burkholderia pseudomallei causes the tropical infection melioidosis. Melioidosis usually manifests as pneumonia or sepsis and is endemic in northeast Thailand and found in other parts of Southeast Asia as well as northern Australia. The purpose of our study is to characterize the immune and inflammatory response of human cells when they are infected with Burkholderia pseudomallei, and determine how these responses differ between Southeast Asian individuals based on genetic sequence. Examining the association between an individual’s cellular response to infection and the variations in their genetic sequence may help us understand how these genes control the inflammatory response.

As a part of our study, we ask eligible individuals to undergo a blood draw and a bronchoscopy (a procedure to obtain cells from the lungs) at Harborview Medical Center.

Participants will be paid $150 for completing the study visit.

Participant Eligibility

  • Between 18 and 50 years of age
  • Identify as Asian, with ancestors from mainland southeast Asia (Laos, Thailand, Cambodia, Malaysia, Vietnam, Myanmar/Burma) or southern China
  • Generally healthy without any chronic medical conditions & not currently taking any medications (prescription or over the counter) other than birth control
  • Non-­smoker


(206) 637-2585

Additional Study Details

Full Study Title
Blood and Lung Responses to B. pseudomallei in SE Asians

Study ID: STUDY00001438
Start Date: 03/28/2017
End Date: 02/19/2021

T. Eoin West, MD, MPH

Accepts Healthy Volunteers?

Study Site(s)

Harborview Medical Center

325 9th AVE
Seattle, Washington 98104


Use the link below to send a message to the study coordinator, or call the number above to speak directly with a study representative.

I am interested in this research study.