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Study of Healthy Aging and Physical function with Elamipretide (SHAPE)

Study of Healthy Aging and Physical function with Elamipretide (SHAPE)

We had reported health benefits from single dose Elamipretide injection in older adults.

The goal of this study is to establish the safety and tolerability of 4-weeks of daily subcutaneous injections in older adult and explore the potential benefits from skeletal muscle, cognitive function to biomarkers of aging. In addition, to serve as stepping stone toward larger scale clinical trials aimed at understanding how Elamipretide may help reduce key signs of aging.

The study includes: a screening/baseline phase (two onsite visits), an intervention period (4-week daily injection of study drug), a mid-intervention check-in phone call, a post-intervention phase (two onsite visits), and a follow-up phase that includes a phone call approximately two weeks after your final visit.

You will be reimbursed $400 for completing the study and transportation costs will be covered.

Participant Eligibility

We are seeking individuals 65-80 yr who are free of chronic disease and are able to attend 2 baseline visits, 4-week daily injection of study drug, and 2 post interventional visits at Fred Hutchinson Cancer Center.

Contact

Sophia Liu
(206) 543-0209

Additional Study Details

Full Study Title
Open-Label, Single-Arm Phase 2a Pilot Study to Evaluate the Safety and Tolerability of a Daily Subcutaneous Dose of Elamipretide in Older Adults

Study ID: 20253531
Start Date: 10/31/2025
End Date: 10/23/2026

Investigator(s)
David Marcinek, PhD
Suman Jayadev, MD

Accepts Healthy Volunteers?
Yes

Study Site(s)

Fred Hutchinson Cancer Center Prevention Center

1100 Fairview Avenue N Level E of the Robert M, Arnold Building
Seattle, Washington 98109



Interested?

Use the link below to send a message to the study coordinator, or call the number above to speak directly with a study representative.

I am interested in this research study.

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