The Washington National Primate Research Center (WaNPRC) and the ITHS are pleased to sponsor the Ignition Award pilot study program, focusing on the use of nonhuman primate models of human disease. The purpose of this award is to explore innovative areas of nonhuman primate (NHP) research and generate preliminary data to serve as a basis for submission of new research grant applications (e.g. R01-type grant to NIH or other funding agency) and/or subsequent clinical studies.
There will be up to three (3) awards: one with the primary focus on translational applications; and up to two pilot awards, focusing on the development or enhancement of the use of non-human primates as animal models.
This program is designed to support innovative studies utilizing resources within the WaNPRC. Nonhuman primates are the preeminent animal model of the human condition. This award program will facilitate use of NHP models and services of the WaNPRC and resources within the ITHS to provide information applicable to subsequent grant and/or clinical studies. This program will provide an opportunity to advance research programs developing and expanding the use of nonhuman primates in research of human diseases, also, by operating jointly with the ITHS, advance the translational process of development and use of therapeutics, diagnostics or device development.
Examples of translational projects include, but are not limited to:
NOTE: There will no option for no-cost extensions or carry-forward. This is an absolute end date.
The application form can be requested at wanprc.org. No UW GC1 is necessary.
No applications time stamped after 11 p.m. on March 3 will be considered.
Reviews are performed utilizing the standards described above. Applicants will be notified of their status by April 3, 2017. Applicants will receive a copy of the reviewers’ notes of their application.
NOTE: The PIs receiving awards are responsible for securing approval from the UW Institutional Animal Care and Use Committee before a new project can begin.
Investigators are offered assistance with their applications and budgets by WaNPRC staff. Budget review before submission of the application is advised, to ensure that the correct pricing is used. Requests for assistance can be sent to via email to: PrimateITHS@wanprc.org.
Budget period is anticipated to begin May 1, 2017, and must be spent by April 30, 2018. There will not be any option for a no-cost extension or carry-forward.
Unsuccessful applicants may resubmit their applications for the next round up to a total of two (2) times. The Review Committee may deny the opportunity to resubmit an application if the reviewers determine the application does not meet the intent of the program.
Any research scientist or research faculty can apply except those who have received an ITHS/Primate Center Ignition Award within the previous three years.
The Center particularly wants to encourage applications from early-stage investigators, post-doctoral fellows and tenure track Assistant Professors (or equivalent). This is an opportunity to pursue innovative research projects or collect preliminary data that can provide proof of concept and lead into future funding
The combined Research Review Committee (RRC) for the Ignition Award applications will consist of members of the WaNPRC, and the ITHS Drug and Device Advisory Committee (DDAC). Members of the committee are selected to provide interdisciplinary insight into the proposed research. The committee is composed of core and affiliate scientists. If potential conflict of interest exists, ad hoc members will be appointed. If the committee does not feel the membership includes the necessary scientific expertise to provide an adequate review, an ad hoc reviewer will be added for that application.
As needed, the WaNPRC will also invite representation from CoMotion for guidance on innovation represented by the technology.
Applications will be critiqued and scored by the RRC. It is anticipated that the projects with the lowest score/highest priority will be funded. Based on funding levels, it is anticipated that two or three projects will be funded during this 2016 review cycle.
Reviews are performed according to the following standards:
Ignition Awards are an investment in translational research to improve human health. Meetings with ITHS representatives to assess the effective utilization of ITHS resources and required progress and results reporting are important aspects that aid in evaluating the success of this funding mechanism.
ITHS and WaNPRC each have specific requirements for reporting.
The ITHS requires the following reports and presentations (if applicable):
The WaNPRC requires an annual report; this will be included with the Annual Progress Report to the sponsor. This will be due in Jan-Feb 2018.
Quarterly in-person meetings with an ITHS representative may be requested to track the progress of funded activities.
The WaNPRC and the ITHS reserves the right to publicly disclose information about its granting activities. ITHS communications to the public may include lists of funded applications, the names of principal investigators and applicant institutions and departments, titles of proposed activities, and reports about progress and outcomes. Please note that records produced at the University of Washington are subject to the Washington State Public Records Act, Chapter 42.56 RCW.
NIH defines human clinical research as research with human subjects that is: (1) Patient-oriented research. Research conducted with human subjects (or on material of human origin such as tissues, specimens and cognitive phenomena) for which an investigator (or colleague) directly interacts with human subjects. Excluded from this definition are in vitro studies that utilize human tissues that cannot be linked to a living individual. Patient-oriented research includes: (a) mechanisms of human disease, (b) therapeutic interventions, (c) clinical trials, or (d) development of new technologies. (2) Epidemiologic and behavioral studies. (3) Outcomes research and health services research. Note: Studies falling under Exemption 4 for human subjects research are not considered clinical research by this definition.
Translation: The process of turning observations in the laboratory, clinic and community into interventions that improve the health of individuals and the public.
Translational Science: The field of investigation focused on understanding the scientific and operational principles underlying each step of the translational process.
Source: Definitions provided by the National Center for Advancing Translational Sciences
Translational research includes:
Source: Based on Institutional Clinical and Translational Science Award (U54) RFA-RM-07-007 CTSA RFA
Using this definition in our review and funding programs, the translational potential of research is rated as:
|Chin, Michael||Pharmacokinetics, organ toxicity and immunogenicity of recombinant tafazzin in|
non human primates
|Cardiology||University of Washington||April, 2016|
|Horwitz, Greg||Cell-type specific promoter sequences for targeting NHP neurons||Physiology and Biophysics||University of Washington||April, 2016|
|Kean, Leslie||Creating a Novel Model for the Treatment of Graft-versus-Host-Disease in Rhesus Macaques||Pediatrics||University of Washington||April, 2016|
|Isoherranen, Nina||Maternal phthalate kinetics in a nonhuman primate model||Pharmaceutics||University of Washington||April, 2015|
|Perlmutter, Steve||NHP Model for cervical myelopathy and therapeutic use of electrical stimulation||Physiology and Biophysics||University of Washington||April, 2015|
|Smith, Jason||A Rhesus model to uncover the role of α-defensins in rotaviral infection||Microbiology||University of Washington||April, 2015|
|Clark, Edward||Testing CD180-based Hepatitis B virus vaccine in macaques||Microbiology/Immunology||University of Washington||March, 2014|
|Neitz, Maureen||In vivo directed evolution of AAV vectors that transduce photoreceptors and the retinal pigment epithelium when injected into the vitreous||Ophthalmology||University of Washington||March, 2014|
|Adams-Waldorf, Kristina||Surfactant Protein A to prevent pre-term birth||Obstetrics and Gynecology||University of Washington||March, 2014|
|Kiem, Hans-Peter||Development of an in vivo model of Hepatitis C virus infection, replication and pathogenesis||Clinical Research||Fred Hutchinson Cancer Research Center||April, 2013|
|Riddell, Stanley||Evaluating the safety of T-cells engineered to express chimeric antigen receptors for ROR1 and a tumor-specific epitope of EGFR||Clinical Research||Fred Hutchinson Cancer Research Center||April, 2013|
|Moshiri, Mariam||Fetal lung maturity assessment with MRI using fetal lung to liver signal intensity ratio and MR spectroscopy||Radiology||Fred Hutchinson Cancer Research Center||April, 2013|
|Horwitz, Greg||Targeted Genetic Manipulation of NHP Neurons in Vivo.||Physiology and Biophysics||University of Washington||February, 2012|
|Robinson, Farrel||Dissolution of perineuronal nets to aid adaptation to a vestibular prosthesis.||Biological Structure||University of Washington||February, 2012|
|Curnow, Eliza||M. fascicularis model for cancer-oocyte target SAS1B.||Reproductive Biology and Stem Cell Core, Reproductive and Developmental Sciences Division, Washington National Primate Research Center||N/A||February, 2012|
|Murray, Charles||Transplantation of M. nemestrina induced pluripotent stem cell (MniPSC) u2013 derived cardiomyocytes into nonhuman primates after myocardial infarction||Pathology and Bioengineering||University of Washington||April, 2011|
|Lieber, Andre||Safety studies with a high affinity companion therapeutic for monoclonal antibodies to treat cancer||Medicine||University of Washington||April, 2011|
|Phillips, James||Vestibular prosthesis for bilateral and uncompensated unilateral loss||Otolaryngology||University of Washington||April, 2011|
|Juul, Sandra||A Novel Non-Human Primate Model of Neonatal Stress and Sedative Drug Use||Pediatrics||University of Washington||March, 2010|
|Zhang, Glenn||Identification of Molecular Signature of Successful Influenza Vaccinations||Animal Sciences||Oklahoma State University||March, 2010|
|Ho, Rodney||Neuro-Imaging of a Novel CNS Targeted Drug Delivery Device in Primates||Pharmaceutics||University of Washington||January, 2010|