The Clinical and Translational Science Award (CTSA) Program has established a collaborative research network called the Trial Innovation Network. The Trial Innovation Network is comprised of more than 50 medical research institutions in 31 states funded by the CTSA Program.
The goal of the Trial Innovation Network is to execute multi-site trials better, faster, and more economically. To achieve this, the Network features a single IRB system, master contracting agreements, quality by design approaches, and a focus on evidence-based strategies for recruitment and patient engagement. The Network will also serve as a national laboratory to study, understand, and accelerate the process of conducting clinical trials.
Investigators can engage the Trial Innovation Network through consultations and services to support multi-center clinical trials and studies. Consultations may lead to clinical protocols that can be implemented at CTSA institutions across the country.
All proposals should be reviewed and approved by the ITHS Hub Liaison Team prior to submission. Please contact us through the form below.
The following types of services and initial consultations are provided by the Trial Innovation Network:
For more information on the process for requesting Trial Innovation Network services and consultations, go to https://trialinnovationnetwork.org/definition-of-services-and-initial-consults/.
All requests must be reviewed, approved, and submitted by the ITHS Hub Liaison Team, please begin by filling out the “Request an ITHS TIN consultation” form below.
If you are an investigator from one of the ITHS partner institutions or collaborating organizations, you may be selected to participate as a site on a Trial Innovation Network study. If you decide to participate as a site, ITHS faculty and staff are here to help support local study start up. This includes cohort identification services, access to SMART IRB, utilization of the FDP-CTSA Standard Agreement, and answers to questions about working on a CTSA Trial Innovation Network study.
The Trial Innovation Network automatically notifies ITHS when selecting local sites for participation in Network studies. We will reach out to you to let you know we are here to help. If you are thinking of participating in a Trial Innovation Network study and haven’t heard from us, or have general questions about this process, please feel free to contact us through the form below.
The Trial Innovation Network offers regular webinars. Some webinars are CTSA-specific, but many are general clinical research-related topics. All Network webinars are open and free to attend.
Investigators who have a full time faculty appointment at the University of Washington may submit a proposal to the Trial Innovation Network requesting a Service or Initial Consultation. Proposals must be submitted by ITHS on the investigator’s behalf.
Recent policy changes by the NIH and DHHS require the use of a single IRB of record for multi-site research to reduce redundant IRB review and to streamline investigator submission processes.
The Trial Innovation Network has established three Central IRBs (CIRBs), which are based on the SMART IRB Authorization Agreement. This service will provide CIRB services to a funded multi-center clinical trial.
The Trial Innovation Network CIRB will also provide resources, tools, and a web-based platform (SMART IRB Exchange) to operationalize the CIRB. The goal is to ensure all site investigators understand the process for initiating the use of a CIRB at their local institution, as well how to submit and report to the CIRB from initial submission to study closeout.
The complexity of contract negotiations can be a major barrier to timely study start-up. The Trial Innovation Network can help you save time by implementing the use of the Federal Demonstration Partnership (FDP)-CTSA Standard Agreement for your multi-site study. This streamlined process accelerates site participation in clinical trials by reducing delays due to contract negotiations.
Please contact us if you’d like to receive a copy of the FDP-CTSA Standard Agreement.
The University of Washington has agreed to utilize the CTSA Smart IRB and the Accelerated Clinical Trial Agreement to facilitate single IRB reliance and standardize contracts. This is an individual agreement with each institution; for more information about contracting and IRB standard agreements, please refer to the following institutional contacts:
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The National Institutes of Health (NIH) will require most applications for multi-site studies conducting the same protocol at each site and which are received on or after January 25, 2018 to describe the use of a single Institutional Review Board (IRB). ...
15 November, 2017 0 Likes
The CTSA Trial Innovation Network (TIN) aims to make multi-site clinical trials as efficient as possible by reducing effort and cost. To further this mission, the TIN produces a regular webinar series to disseminate novel techniques and trainings to research teams. ...
13 April, 2018 1 Like